The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy

Apr 13, 2011Gastrointestinal endoscopy

How Poor Bowel Cleaning Increases Missed Growths and Leads to Earlier Repeat Colonoscopies

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Abstract

Among 12,787 colonoscopies, 24% involved suboptimal bowel preparation.

In 3047 patients with suboptimal preparation, 17% underwent repeat colonoscopy within <3 years.
Factors linked to early repeat colonoscopy included lack of cecal intubation (odds ratio 3.62) and polyp detection (odds ratio 1.55).
Of 216 repeat colonoscopies with optimal preparation, 198 adenomas were found, with 83 detected only on the second examination.
The adenoma miss rate was 42%, while the advanced adenoma miss rate was 27%.
For colonoscopies repeated within <1 year, adenoma and advanced adenoma miss rates were 35% and 36%, respectively.

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BACKGROUND: There are no guidelines for the recommended interval to the next examination after colonoscopy with suboptimal bowel preparation.

OBJECTIVE: To identify factors associated with early repeat colonoscopy after initial examinations with suboptimal preparations and to measure adenoma miss rates in this context.

DESIGN: Retrospective study.

SETTING: Hospital-based endoscopy unit.

PATIENTS: Bowel preparation quality was recorded in 12,787 patients.

RESULTS: Of 12,787 colonoscopies, preparation quality was suboptimal (poor or fair) in 3047 patients (24%). Among these 3047 patients, repeat examination was performed in <3 years in 505 (17%). Factors associated with early repeat colonoscopy included lack of cecal intubation (odds ratio [OR] 3.62, 95% confidence interval [CI], 2.50-5.24) and finding a polyp (OR 1.55, 95% CI, 1.17-2.07). Among 216 repeat colonoscopies with optimal preparation, 198 adenomas were identified, of which 83 were seen only on the second examination, an adenoma miss rate of 42% (95% CI, 35-49). The advanced adenoma miss rate was 27% (95% CI, 17-41). For colonoscopies repeated in <1 year, the adenoma and advanced adenoma miss rates were 35% and 36%, respectively.

LIMITATIONS: Single-center, retrospective study.

CONCLUSION: Although a minority of patients undergo early repeat examination after colonoscopies done with suboptimal bowel preparation, the miss rates for colonoscopies done with suboptimal bowel preparation were high, suggesting that suboptimal bowel preparation substantially decreases colonoscopy effectiveness and may mandate an early follow-up examination.

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The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy

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