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Succinate Modulation as a Biochemical Correlate of Metabolic and Neurobehavioral Changes Associated With Intermittent Fasting in Obesity
Changes in Succinate Linked to Metabolism and Brain-Related Behavior During Intermittent Fasting in Obesity
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Abstract
Switching to intermittent fasting or control chow reduced body weight and improved glucose tolerance in a mouse model of obesity.
- Intermittent fasting and control chow led to reduced fat mass and improved glucose tolerance compared to a high-fat diet.
- Control chow combined with intermittent fasting uniquely enhanced exploration behavior and reduced anxiety-like behavior in mice.
- Obesity induced neuroinflammation in the hippocampus, as shown by transcriptomic analysis.
- Metabolomic analysis revealed a decrease in plasma succinate levels and an increase in liver and brown adipose tissue levels in mice on control chow with intermittent fasting.
- Succinate supplementation replicated the metabolic and behavioral benefits of intermittent fasting and reduced hippocampal inflammation.
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