Long-lasting blood sugar control with semaglutide treatment in an adult with latent autoimmune diabetes and multiple autoimmune conditions: a case report and review

A 55-year-old woman with Latent Autoimmune Diabetes in Adults (LADA) achieved durable glycemic control and significant weight loss over five years using semaglutide.

• The patient was initially misdiagnosed with type 2 diabetes and presented with several autoimmune disorders alongside class II obesity.
• Laboratory tests confirmed the diagnosis of LADA, showing positive anti-glutamic acid decarboxylase antibodies and preserved fasting C-peptide levels.
• Semaglutide was initiated after discontinuing metformin due to the patient's obesity and residual pancreatic function.
• The patient maintained stable beta-cell function throughout the follow-up period without needing insulin.
• Transitioning from injectable to oral semaglutide did not affect metabolic stability.
• Limited literature supports the use of GLP-1 receptor agonists in LADA, with only two eligible case reports identified.

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