Steven A. Brown and how body temperature cycles help align daily biological rhythms

The master pacemaker in the brain's suprachiasmatic nucleus is synchronized primarily by light-dark cycles.

• The mammalian circadian system has a hierarchical structure with a central pacemaker and peripheral oscillators.
• Peripheral clocks in most body cells synchronize with various systemic signaling pathways.
• Feeding-fasting cycles, cellular dynamics, and endocrine rhythms are among the factors that influence peripheral oscillators.
• Shallow rhythms of body temperature may serve as timing cues for these peripheral circadian clocks.

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