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Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
Creating new 1,2,4-triazole-based compounds and testing their potential to block digestive enzymes α-amylase and α-glucosidase in lab and computer studies
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Abstract
The synthesized Schiff bases showed α-amylase and α-glucosidase inhibitory activities with IC values ranging from 17.09 ± 0.72 to 45.34 ± 0.03 μM.
- Inhibitory activity varied among the synthesized compounds, with some displaying significant activity against α-amylase and α-glucosidase.
- Specific compounds exhibited IC values of 17.09 ± 0.72 μM for α-amylase and 16.35 ± 0.42 μM for α-glucosidase.
- The reference drug, glimepiride, had lower IC values of 15.04 ± 0.02 μM for α-amylase and 13.02 ± 0.11 μM for α-glucosidase.
- Structural differences in the synthesized analogues may influence their inhibitory activities on the targeted enzymes.
- Molecular docking studies were performed to investigate binding interactions of the most active analogues with enzyme active sites.
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