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An insight on medicinal attributes of 1,2,3‐ and 1,2,4‐triazole derivatives as alpha-amylase and alpha-glucosidase inhibitors
Medicinal properties of 1,2,3- and 1,2,4-triazole compounds as blockers of enzymes that break down starch and sugars
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Abstract
Medicinally privileged triazole compounds may serve as promising agents for developing new antidiabetic drugs.
- Diabetes Mellitus is characterized by high glucose levels due to inadequate insulin secretion.
- α-amylase and α-glucosidase are key enzymes that break down complex carbohydrates into glucose.
- Inhibiting these enzymes is an effective therapeutic strategy for managing diabetes.
- Various molecular hybrids, such as pyridazine-triazole and pyrazoline-triazole, have shown promising antidiabetic activity.
- The review discusses the structure-activity relationship and enzyme inhibitory activity of these triazole compounds.
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