À propos du système circadien chez l’homme : de l’horloge interne à la sécrétion de mélatonine

Mar 20, 2016Annales pharmaceutiques francaises

The human body clock and how it controls melatonin release

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Abstract

Circadian rhythm desynchronization can occur due to factors like shift work, aging, and certain psychiatric conditions.

  • The internal biological clock is located in the suprachiasmatic nuclei of the anterior hypothalamus.
  • Clock genes and environmental factors help synchronize this clock to a 24-hour cycle.
  • Disruptions to the circadian system can lead to misalignment with astronomical time.
  • The circadian system includes the clock, the retinohypothalamic tract, and melatonin from the pineal gland.
  • Light and melatonin have phase response curves that may aid in treating sleep circadian disorders.

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