Clinical and experimental medicine

Aging of immune T cells and heart and blood vessel diseases

Updated

Abstract

Immunosenescence is associated with significant changes in T cell immunity, impacting health and survival in the elderly.

  • Age-related immune changes can lead to a weakened immune response in older individuals.
  • Notable alterations in T cell immunity include reduced diversity of T cell receptors and shifts in T cell populations.
  • Senescent T cells are capable of producing high levels of proinflammatory substances.
  • These senescent T cells may contribute to the development of chronic inflammatory diseases, including cardiovascular conditions.
  • The potential role of senescent T cells in cardiovascular diseases highlights their impact on health in older populations.

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