Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1–2 hypertension

Jul 9, 2010Blood pressure monitoring

Combined effects of telmisartan and amlodipine on daily blood pressure in mild to moderate high blood pressure

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Abstract

Combination therapy of telmisartan (80 mg) and amlodipine (10 mg) resulted in a 22.4 mmHg reduction in 24-hour systolic blood pressure.

Combination therapies lowered 24-hour blood pressure more effectively than monotherapies at all doses examined.
The highest dose combination resulted in a mean reduction of -22.4 mmHg systolic and -14.6 mmHg diastolic blood pressure.
Monotherapy with amlodipine (10 mg) led to reductions of -11.9 mmHg systolic and -6.9 mmHg diastolic blood pressure.
Monotherapy with telmisartan (80 mg) resulted in reductions of -11.0 mmHg systolic and -6.9 mmHg diastolic blood pressure.
Response and control rates for achieving 24-hour blood pressure below 130/80 mmHg were significantly higher with combination therapy.

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BACKGROUND: Evaluation of combination therapy with antihypertensive agents by clinic blood pressure (BP) measurements may yield results that differ from out-of-office BP readings. This is of clinical relevance because out-of-office BP values are of prognostic importance. We studied the effects of combining telmisartan and amlodipine on ambulatory BP in patients with stages 1-2 hypertension.

METHODS: We conducted an 8-week, placebo-controlled, double-blind, 4x4 factorial design trial in which 562 patients with clinic diastolic BP at least 95 and 119 mmHg or less were randomized to receive telmisartan (0, 20, 40, or 80 mg) and/or amlodipine (0, 2.5, 5, or 10 mg). Ambulatory BP monitoring was performed at baseline and after 8 weeks of treatment; the end points of interest were the changes from baseline in 24-h systolic and diastolic BP. Secondary end points included the proportion of responders (> or =10 mmHg BP reduction from baseline and/or <130/80 mean 24-h BP) and controlled patients (<130/80 mmHg mean 24-h BP).

RESULTS: Combination therapies of telmisartan and amlodipine lowered 24-h BP to a larger extent than the corresponding monotherapies at all doses. Mean reductions from baseline in 24-h BP for the combination of the highest doses of telmisartan (80 mg) and amlodipine (10 mg) were -22.4/-14.6 versus -11.9/-6.9 mmHg for amlodipine (10 mg) and -11.0/-6.9 mmHg for telmisartan (80 mg) (P<0.0001 for each comparison). In addition, BP response and control rates (24-h BP <130/80 mmHg) were significantly higher with the combination therapy versus the monotherapy groups.

CONCLUSION: These findings show that telmisartan and amlodipine in combination provide substantial 24-h BP efficacy that is superior to either monotherapy in patients with stages 1 and 2 hypertension.

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Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1–2 hypertension

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