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Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases
Using body clock timing to treat long-term inflammatory diseases
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Abstract
Circadian rhythms have a periodicity of approximately 24 hours and influence various biological processes.
- Circadian rhythms play a significant role in regulating the inflammatory response.
- An inflammatory environment may disrupt normal circadian rhythms.
- Chronic inflammatory diseases like sepsis, asthma, and rheumatoid arthritis exhibit circadian patterns.
- Targeting the biological clock and its components could lead to novel pharmacological strategies.
- Chronotherapy, in combination with small molecule modulators, may enhance treatment efficacy and reduce toxicity.
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