The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

Alterations of clock genes across 32 cancer types are associated with key oncogenic pathways and patient outcomes.

• Expression changes in clock genes may relate to tumor stage and subtype in various cancers.
• Correlations between clock gene expression and other genes differ between cancerous and normal tissues.
• Interactions between clock genes and clinically actionable genes were identified through multiple analytical approaches.
• Clock gene expression could influence sensitivity to anti-cancer drugs in cancer cell lines.

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