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Thiamine ameliorates subacute ruminal acidosis–induced mastitis in goats and is associated with modulation of the NF-κB/NLRP3/CLOCK axis and rumen microbial homeostasis
Thiamine reduces inflammation of the udder caused by digestive acid imbalance in goats by affecting immune pathways and gut microbes
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Abstract
Thiamine supplementation in high-concentrate diets reversed changes in ruminal pH and inflammation in 32 mid-lactating Saanen goats.
- A high-concentrate diet decreased ruminal pH and induced microbial dysbiosis.
- This diet led to increased plasma levels of lipopolysaccharides (LPS) and systemic inflammation.
- Elevated cytokine expression was observed, contributing to a significant decline in milk yield and quality.
- Thiamine supplementation in the high-concentrate diet stabilized ruminal pH and improved microbiota composition by enriching beneficial bacteria.
- Reduced inflammatory cytokine levels were noted with thiamine, along with altered activation of specific inflammatory pathways in the mammary tissue.
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