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Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice
Evening high-fat meals change the liver’s daily clock and fat-making gene activity in mice
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Abstract
Timed high-fat diets may alter the expression of hepatic clock genes and lipogenic genes.
- Certain hepatic clock genes such as Clock, Bmal1, Per2, and Cry2 showed significant changes in their rhythms and amplitudes after a high-fat diet.
- Changes in clock gene expression were associated with altered circadian rhythms of PPARα expression.
- PPARα target genes, including CYP7A1 and DGAT, displayed marked changes in their expression rhythms and amplitudes.
- High-fat diets resulted in increased hepatic cholesterol and triglyceride levels.
- These findings suggest that high-fat diets consumed at night could lead to hepatic lipid accumulation.
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