Cureus

A Rare Case of Low Platelet Count Linked to Tirzepatide

Updated

Abstract

A 47-year-old male experienced isolated thrombocytopenia of 6000/µL after increasing tirzepatide dosage to 12.5 mg.

  • The patient developed an ecchymotic, petechial rash within a week of the dosage increase.
  • Secondary causes of thrombocytopenia were ruled out, suggesting a direct association with tirzepatide.
  • Treatment with intravenous immunoglobulin (IVIG) and steroids led to a return of platelet counts to baseline.
  • Findings indicate a potential immune-mediated mechanism for severe thrombocytopenia linked to tirzepatide.
  • Clinical awareness of this rare side effect may help prevent serious complications.

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Funding

Competing interests

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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