Diabetes, obesity & metabolismJun 3, 2026

Short-Term Combined Tirzepatide and Metformin Treatment for Overweight Chinese Women With Polycystic Ovary Syndrome

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jun 4, 2026

Abstract

The combination of low-dose tirzepatide and metformin led to a greater reduction in body weight of -10.4 ± 3.5 kg compared to metformin alone, which had a reduction of -1.7 ± 2.5 kg (p < 0.001).

The combination treatment resulted in a significant decrease in body mass index (BMI) of -4.12 ± 1.37 kg/m compared to -0.68 ± 1.82 in the metformin group (p < 0.001).
Visceral adipose tissue (VAT) reduction was substantially greater in the combination group (-34.13 ± 15.33 cm) compared to the metformin group (-4.67 ± 9.59 cm, p < 0.001).
Improvements in reproductive endocrine-metabolic parameters were observed in the combination group.
Menstrual cycle recovery rates were higher in the combination group (p = 0.013).
The total pregnancy rate was also significantly higher in the combination group compared to the metformin group (p = 0.014).

Simplified

AIMS: This study aimed to assess the effects of low-dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight/obese women with polycystic ovary syndrome (PCOS).

MATERIALS AND METHODS: Sixty overweight/obese women with PCOS were randomised to the MET group (1000 mg twice daily [BID]) or the COM group (MET: 1000 mg BID, tirzepatide: 5 mg once weekly [QW]) for 16 weeks. The primary outcome was the change in body weight. Secondary outcomes included changes in anthropometric measures other than body weight, body composition, reproductive hormone levels, metabolic and endocrine parameters, inflammatory markers and menstrual cycle regularity. All outcomes were assessed at baseline and week 16. After week 16, participants were switched to MET monotherapy. Barrier contraception was required for 8 weeks and pregnancy outcomes were subsequently evaluated between weeks 25 and 48.

RESULTS: After 16 weeks of treatment, compared with the MET group, the COM group resulted in greater reductions in weight (-1.7 ± 2.5 kg vs. -10.4 ± 3.5 kg; p < 0.001), body mass index (BMI) (-0.68 ± 1.82 vs. -4.12 ± 1.37 kg/m; p < 0.001), visceral adipose tissue (VAT) (-4.67 ± 9.59 vs. -34.13 ± 15.33 cm; p < 0.001) and reproductive endocrine-metabolic parameters. Menstrual cycle recovery and total pregnancy rate were higher in the COM group than in the MET group (p = 0.013 and p = 0.014, respectively). 2 2

CONCLUSIONS: In overweight/obese women with PCOS, low-dose tirzepatide combined with MET was associated with greater reductions in body weight and visceral fat, along with improvements in metabolic and reproductive outcomes compared with MET monotherapy.

TRIAL REGISTRATION: ChiCTR2400090908; chictr.org.cn.

Full Text

Full text is available at the source.

View Full Text ↗

Short-Term Combined Tirzepatide and Metformin Treatment for Overweight Chinese Women With Polycystic Ovary Syndrome

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the glp-1 therapies brief