Diabetes care

Tirzepatide linked to lower protein in urine in people with type 2 diabetes: combined analysis of clinical trials

Updated

Abstract

Tirzepatide reduced urine albumin-to-creatinine ratio (UACR) by an adjusted mean of -26.3% compared to pooled comparators at week 40/42.

  • The percentage change in UACR for tirzepatide was -19.3% for 5 mg, -22.0% for 10 mg, and -26.3% for 15 mg.
  • Similar reductions in UACR were observed across pooled placebo, active, and insulin comparator studies.
  • Greater UACR reductions were noted in subgroups with baseline UACR ≥30 mg/g.
  • Mediation analysis indicated that about half of the UACR reduction may be related to weight loss.
  • There was no significant difference in estimated glomerular filtration rate (eGFR) between tirzepatide and comparators at week 40/42.

Simplified

Full Text

We can’t show the full text here under this license.

Funding

Competing interests

Duality of Interest. K.R.T. is supported by National Institutes of Health research grants R01MD014712, U2CDK114886, UL1TR002319, U54DK083912, U01DK100846, OT2HL161847, and UM1AI109568 and Centers for Disease Control and Prevention project number 75D301-21-P-12254. She has also received investigator-initiated grant support from Travere and Bayer Pharmaceuticals outside of the submitted work. K.R.T. reports consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Novo Nordisk, and Travere. I.P., A.Ha., R.T., R.J.W., and A.He. are employees and shareholders of Eli Lilly and Company. D.Z.I.C. has received honoraria from Boehringer Ingelheim-Lilly, Merck, AstraZeneca, Sanofi, Mitsubishi-Tanabe, AbbVie, Janssen, Bayer, Prometic, Bristol-Myers Squibb, Maze, Gilead, CSL-Behring, Otsuka, Novartis, Youngene, Lexicon, and Novo Nordisk and has received operational funding for clinical trials from Boehringer Ingelheim-Lilly, Merck, Janssen, Sanofi, AstraZeneca, CSL-Behring, and Novo Nordisk. N.S. recognizes grant support from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche Diagnostics; has received consulting fees from Abbott Laboratories, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Hanmi Pharmaceuticals, Janssen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Roche Diagnostics, and Sanofi; and has received payment for lectures or manuscript writing from Abbott Laboratories, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Janssen, and Novo Nordisk. H.J.L.H. acts as a consultant for AstraZeneca, Bayer, Boehringer Ingelheim, CSL-Behring, Eli Lilly and Company, Gilead, Janssen, Novartis, Novo Nordisk, and Travere and received research support from AbbVie, AstraZeneca, Boehringer Ingelheim, Janssen, and Novo Nordisk. No other potential conflicts of interest relevant to this article were reported.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free