Tirzepatide helps hard-to-treat diabetes in an adult woman with Prader-Willi syndrome

Prader-Willi syndrome (PWS) results from the loss of expression of paternally inherited genes in the 15q11.2-q13 region.

• PWS is a complex genetic disorder that affects multiple body systems.
• The disorder is characterized by severe muscle weakness and feeding difficulties in infancy.
• As children grow, they may develop an uncontrollable appetite, known as hyperphagia.
• Without careful management of eating behaviors, individuals with PWS can develop severe obesity.
• Severe obesity in PWS is associated with an increased risk of type 2 diabetes mellitus.

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