Light and internal clock control proteins identified by mapping their direct targets in Neurospora

The Neurospora crassa circadian regulator White Collar Complex (WCC) controls the expression of 24 transcription factor genes.

• WCC is a blue-light receptor and a key transcription factor in the circadian clock.
• It regulates about 20% of all genes, influencing daily rhythms and light responses.
• WCC binds to hundreds of genomic regions in response to light, including gene promoters.
• The clock-controlled gene adv-1 is among those directly regulated by WCC, affecting daily developmental rhythms.
• These findings establish connections between the circadian activator WCC and downstream regulatory pathways.

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