Current opinion in neurobiology

How Rod and Cone Light Sensors Differ in Processing Signals and the Role of Calcium Balance

Updated

Abstract

Changes in the cytoplasmic concentration of Ca2+ in cones are far larger and faster than in rods.

  • Rod and cone photoreceptors have similar but distinct enzymes in their light response pathways.
  • The volume of the cell influences how each type of photoreceptor maintains Ca2+ levels.
  • Rods and cones differ in the speed of clearing Ca2+ from their outer segments.
  • The way Ca2+ is buffered in the cytoplasm varies between rods and cones.
  • Ca2+ enters through cGMP-gated ion channels at different rates in rods and cones.

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