Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Trehalose's overlooked roles in Alzheimer's: gut, brain, and cell cleanup signals beyond common targets

Updated

Abstract

Trehalose is a promising therapeutic candidate for Alzheimer's disease.

  • Trehalose may induce autophagy, a process that helps clear misfolded proteins.
  • It is associated with the clearance of amyloid-β and hyperphosphorylated tau, proteins linked to Alzheimer's disease.
  • Emerging evidence suggests that trehalose has a wider range of molecular mechanisms.
  • This broader profile could indicate a greater neuroprotective effect beyond just protein clearance.

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