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Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetes
Links between blood fat and sugar measures and death risk in people with prediabetes
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Abstract
Among 9,574 participants with , elevated levels of the triglyceride-glucose (TyG) index and TyG-waist circumference (TyG-WC) were significantly associated with increased cancer mortality risk.
- Higher quartiles of the were linked to increased all-cause mortality, with quartile 1 showing the lowest mortality rates.
- TyG-waist-to-height ratio (TyG-WHtR) demonstrated a negative correlation with overall survival and cardiovascular disease-specific survival.
- A multivariate analysis indicated a significant positive correlation between the highest quartile of the TyG index and cancer mortality risk.
- Increased TyG-WC levels were significantly associated with cancer mortality in individuals with prediabetes.
- Both TyG-WC and TyG-WHtR were found to have nonlinear correlations with cancer mortality.
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Key numbers
1.957
Cancer Mortality Hazard Ratio Increase
Adjusted hazard ratio for cancer mortality in the highest quartile.
2.397
CVD Mortality Hazard Ratio Increase
Adjusted hazard ratio for cancer mortality in the highest TyG-WC quartile.
1.506
All-Cause Mortality Hazard Ratio Increase
Adjusted hazard ratio for all-cause mortality in the highest TyG-WHtR quartile.