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Abstract
Rats treated with the TRPV1 agonist resiniferatoxin (RTX) demonstrated changes in locomotor activity and body temperature during time-restricted feeding (TRF) but did not show certain metabolic improvements.
- TRF is associated with increased spontaneous locomotor activity before mealtime and a phase shift in clock gene expression, especially in the liver.
- RTX treatment resulted in increased locomotor activity and body temperature at the beginning of the light phase.
- While RTX-treated rats experienced decreased body weight gain and food intake compared to fed controls, they did not show reduced oxygen consumption or improved glucose tolerance typically induced by TRF.
- RTX treatment eliminated the temporal changes in the expression of specific clock genes and leptin levels in the liver.
- The findings suggest that TRPV1 may play a role in mediating the metabolic changes associated with TRF through its influence on liver gene expression and leptin secretion.
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