Adding phosphate to GARU enzyme boosts plant growth signals by stopping GID1 breakdown

Genistein may inhibit gibberellin signaling by targeting the TAGK2 tyrosine kinase, which affects the degradation of the GID1 receptor.

• Gibberellin (GA) signaling involves the degradation of DELLA proteins mediated by the GID1 receptor.
• GARU, a ubiquitin ligase, is responsible for the ubiquitin-dependent degradation of the GID1 receptor.
• Phosphorylation of GARU at Tyr321 by TAGK2 is involved in regulating its interaction with GID1.
• Genistein, a tyrosine kinase inhibitor, promotes GID1 degradation and DELLA accumulation.
• In Arabidopsis, mutations in garu or overexpression of TAGK2 enhance GID1 stability and DELLA degradation.
• GARU reduces seed germination under salt stress, indicating its role in plant responses to environmental conditions.

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