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Abstract
The engineered ultrasound-activatable lipid nanoparticle formulation increased antigen-specific CD8T cell responses by 2.5-fold compared to conventional formulations.
- Sono-adjuvant lipid was developed to provide targeted immune stimulation in lymph nodes.
- Ultrasound activation of the lipid nanoparticles enhanced immune responses by activating specific cellular pathways in antigen-presenting cells.
- The combination of ultrasound with the novel lipid nanoparticles improved lymph node-specific mRNA transfection.
- The strategy effectively boosted antitumor T cell immunity and completely eliminated orthotopic liver tumors in mice.
- The approach may facilitate more precise and effective cancer vaccination therapies.
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