Science (New York, N.Y.)

Unsaturated fat changes clock protein activity to adjust daily rhythms for the season in mice

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Essence

Dietary unsaturated fat shifted seasonal circadian alignment in mice through phosphorylation of PER2 at S662.

Evidence

A mouse diet and photoperiod experiment measured locomotor phase shifting, hypothalamic expression pathways for PUFA-derived oxylipins, and PER2-S662 phosphorylation, including mice whose PER2-S662 could not be phosphorylated.

Caveat

The result is limited to mouse circadian entrainment and specific dietary manipulations, not direct evidence about human seasonal adaptation.

Simplified

Full Text

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Funding

Competing interests

0 of 6
authors report competing interests
6 report none
PubMed
No competing interests reported.

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