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Abstract
PT + MO (1:2) improved gastrointestinal function in mice with gastrointestinal motility disorders caused by PT.
- The combination of Polygala tenuifolia and Magnolia officinalis is associated with improved gastric emptying and small intestine advancing rates.
- Metabolomics identified 17 metabolites in urine and 12 in faeces that are regulated by the PT-MO combination.
- The intervention mechanism involves 11 metabolic pathways in urine and 10 in faeces.
- Key metabolic pathways affected include those related to tyrosine, purine, the tricarboxylic acid cycle, pyruvate, and gluconeogenesis.
- The PT-MO combination may alleviate PT-induced gastrointestinal motility disorders by influencing energy, amino acid, and fatty acid metabolism.
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