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Combination of urine and faeces metabolomics to reveal the intervention mechanism of Polygala tenuifolia compatibility with Magnolia officinalis on gastrointestinal motility disorders
Using urine and stool analysis to understand how Polygala tenuifolia and Magnolia officinalis work together to improve digestive movement disorders
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Abstract
PT + MO (1:2) improved gastrointestinal function in mice with gastrointestinal motility disorders caused by PT.
- The combination of Polygala tenuifolia and Magnolia officinalis is associated with improved gastric emptying and small intestine advancing rates.
- Metabolomics identified 17 metabolites in urine and 12 in faeces that are regulated by the PT-MO combination.
- The intervention mechanism involves 11 metabolic pathways in urine and 10 in faeces.
- Key metabolic pathways affected include those related to tyrosine, purine, the tricarboxylic acid cycle, pyruvate, and gluconeogenesis.
- The PT-MO combination may alleviate PT-induced gastrointestinal motility disorders by influencing energy, amino acid, and fatty acid metabolism.
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