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Abstract
The essential oil from Lippia alba and its major component, citral, demonstrated effective vasorelaxant properties with EC values of 352.73 ± 19.39 μg/mL and 99.34 ± 7.2 μg/mL respectively in the presence of endothelium.
- Both EOLa and citral caused relaxation of aortic smooth muscle, suggesting potential therapeutic effects on vascular function.
- The presence of endothelium enhanced the vasorelaxant action of EOLa and citral.
- Inhibition of nitric oxide synthesis with L-NAME reduced the efficacy of EOLa and citral, indicating a role for nitric oxide in their action.
- EOLa and citral also relaxed contractions induced by a calcium channel agonist and a protein kinase C activator, suggesting multiple mechanisms of action.
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