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Effect of the Lippia alba (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats
Effects of Lippia alba essential oil and its main parts, citral and limonene, on rat airway muscle
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Abstract
Essential oil from Lippia alba showed an EC50 of 148 ± 7 μg/mL in relaxing tracheal smooth muscle.
- Citral and limonene also relaxed tracheal smooth muscle with EC50 values of 136 ± 7 μg/mL and 581 ± 7 μg/mL, respectively.
- Both EOLa and citral exhibited an EC50 of 731 ± 5 μg/mL in muscle contractions induced by Acetylcholine.
- In muscle preparations pre-incubated with 1000 μg/mL of EOLa and citral, both agents blocked calcium influx through voltage-operated calcium channels.
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