Diabetes, obesity & metabolismSep 1, 2026

Combining a Virtual GLP-1 Program and Exercise Support to Improve Body Composition During GLP-1 Weight Loss

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Sep 2, 2026

Abstract

A 12-week virtual lifestyle program may enhance weight and fat loss while preserving muscle mass in adults with obesity undergoing GLP-1 therapy.

GLP-1 receptor agonists can lead to significant weight loss, but often result in loss of lean mass, especially early in treatment.
Physical activity, especially resistance training, is effective for improving fat loss while maintaining muscle mass.
The program included personalized physical activity coaching aimed at optimizing outcomes for individuals on GLP-1 therapy.
Participants had started GLP-1 therapy within the last 8 weeks prior to beginning the program.

Simplified

Glucagon-like peptide-1 (GLP-1) receptor agonists can produce rapid weight loss, but this loss is frequently accompanied by disproportionate loss of lean mass, particularly during the early phase of GLP-1-treatment. Physical activity (PA), particularly resistance training, is the most effective behavioural strategy for enhancing fat reduction while preserving lean mass. Our primary aim was to evaluate whether a 12-week virtual GLP-1 lifestyle companion programme that includes PA coaching was associated with increased weight and fat loss coupled with preservation of muscle mass among adults with obesity who initiated GLP-1 therapy for weight loss ≤ 8 weeks prior to baseline.

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Combining a Virtual GLP-1 Program and Exercise Support to Improve Body Composition During GLP-1 Weight Loss

Abstract

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