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Weight reduction over time in tirzepatide‐treated participants by early weight loss response: Post hoc analysis in SURMOUNT‐1
Weight loss over time with tirzepatide linked to early weight loss response: Analysis from SURMOUNT-1
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Abstract
Among treated with tirzepatide, 90% achieved a weight reduction of 5% or more by Week 72.
- The analysis included 1545 participants, with 278 (18%) identified as late responders and 1267 (82%) as .
- Late responders were typically heavier, with a higher body weight (110.2 kg vs. 103.6 kg) and BMI (39.1 kg/m² vs. 37.7 kg/m²) compared to early responders.
- At Week 24, 70% of late responders reached a 5% weight reduction, increasing to 90% by Week 72.
- The average time for late responders to achieve a 5% weight reduction was 24.8 weeks.
- Higher doses of tirzepatide correlated with greater proportions of participants meeting weight reduction targets.
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Key numbers
250 of 278
Weight Reduction Achievement
achieving ≥5% weight reduction at Week 72.
11.0%
Mean Weight Reduction for
Mean percent body weight reduction at Week 72 for .
22.5%
Mean Weight Reduction for
Mean percent body weight reduction at Week 72 for .