Diabetes, obesity & metabolism

Weight loss over time with tirzepatide linked to early weight loss response: Analysis from SURMOUNT-1

Updated

Abstract

Among treated with tirzepatide, 90% achieved a weight reduction of 5% or more by Week 72.

  • The analysis included 1545 participants, with 278 (18%) identified as late responders and 1267 (82%) as .
  • Late responders were typically heavier, with a higher body weight (110.2 kg vs. 103.6 kg) and BMI (39.1 kg/m² vs. 37.7 kg/m²) compared to early responders.
  • At Week 24, 70% of late responders reached a 5% weight reduction, increasing to 90% by Week 72.
  • The average time for late responders to achieve a 5% weight reduction was 24.8 weeks.
  • Higher doses of tirzepatide correlated with greater proportions of participants meeting weight reduction targets.

Simplified

Key numbers

250 of 278
Weight Reduction Achievement
achieving ≥5% weight reduction at Week 72.
11.0%
Mean Weight Reduction for
Mean percent body weight reduction at Week 72 for .
22.5%
Mean Weight Reduction for
Mean percent body weight reduction at Week 72 for .

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Funding

Competing interests

Jamy Ard received research support from Nestle Healthcare Nutrition, Eli Lilly and Company, Boehringer Ingelheim, Epitomee, Inc., UnitedHealth Group R&D, KVKTech, WW and Novo Nordisk and is a consultant for Nestle Healthcare Nutrition, Eli Lilly and Company, Optum Labs R&D, Novo Nordisk, Intuitive, Regeneron, Brightseed, Amplifier Therapeutics, Amgen and Ingredion. Dr. Ard is an advisory board member for Novo Nordisk, Nestle Healthcare Nutrition, Eli Lilly and Company, WW and Boehringer Ingelheim. He is a member of the International Food Information Council—Assembly, The Obesity Society—President 2024, American Diabetes Association, Society of Behavioural Medicine, Roundtable on Obesity Solutions, American Society for Nutrition and American Society for Nutrition Foundation—Board of Trustees Executive Committee. Kimberly Gudzune was an Associate Professor in the Department of Medicine at the Johns Hopkins University School of Medicine and engaged in this research as a private advisor and not in her capacity as a Johns Hopkins faculty member. She received no compensation for this work. She has received personal fees for participation on advisory boards for Eli Lilly and Company and Novo Nordisk and travel support from Eli Lilly and Company and Novo Nordisk. Her former institution (Johns Hopkins) received grant funding from Novo Nordisk. Since the initial conduct of this research, Dr. Gudzune reports being an employee of the American Board of Obesity Medicine Foundation. Brandi Addison is a speaker for Eli Lilly and Company, Novo Nordisk and Corcept Therapeutics and is an advisory board member for Eli Lilly and Company. She is a member of the American Association of Clinical Endocrinology and The Obesity Society. Ildiko Lingvay received research funding (paid to institution) and/or products from Novo Nordisk, Sanofi, Boehringer‐Ingelheim, Dexcom and received research‐related consulting fees (paid to institution) from Novo Nordisk. She received advisory/consulting fees and/or other support from: AbbVie, Altimmune, Alveus Therapeutics, Amgen, Antag Therapeutics, AstraZeneca, Bayer, Betagenon AB, Bioio Inc., Biomea, Boehringer‐Ingelheim, Carmot, Cytoki Pharma, Eli Lilly and Company, Intercept, Janssen/J&J, Juvena, Keros Therapeutic, Inc., Mediflix, Merck, Metsera, Neurocrine, Novo Nordisk, Pharmaventures, Pfizer, Regeneron, Roche, Sanofi, Shionogi, Source Bio, Structure Therapeutics, TARGET RWE, TERNS Pharma, The Comm Group, WebMD and Zealand Pharma. Clare J. Lee, Dachuang Cao, Casey J. Mast, Adam Stefanski, Beverly Falcon and Donna Mojdami are employees and shareholders of Eli Lilly and Company.
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