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Withaferin A exerts an anti-obesity effect by increasing energy expenditure through thermogenic gene expression in high-fat diet-fed obese mice
Withaferin A may reduce obesity by boosting energy use through heat-producing genes in mice fed a high-fat diet
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Abstract
Treatment with Withaferin A (WFA) increased energy expenditure in mice on a high-fat diet.
- WFA administration improved mitochondrial activity in brown adipose tissue.
- Browning of subcutaneous white adipose tissue was promoted by increasing uncoupling protein 1 levels.
- Phosphorylation of AMP-activated protein kinase (AMPK) in brown adipose tissue was significantly increased.
- WFA activated mitogen-activated protein kinase (MAPK) signaling pathways in both brown and subcutaneous white adipose tissues.
- These changes may contribute to the observed reduction in obesity.
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