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Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue
Cinnamaldehyde may reduce diet-related obesity in mice by turning fat storage into fat burning tissue
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Abstract
Cinnamaldehyde (CA) treatment decreased body weight and fat mass in mice fed a high-fat diet.
- CA administration reduced food intake and serum levels of lipids, free fatty acids, and leptin.
- Insulin sensitivity improved in mice that received CA compared to those on a high-fat diet without CA.
- CA inhibited the enlargement of fat tissue and promoted the browning of white fat tissue.
- Expression of uncoupling protein 1 (UCP1) increased in white adipose tissue following CA treatment.
- CA enhanced levels of specific proteins associated with fat metabolism and energy expenditure in both fat types.
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