International journal of biological macromoleculesFeb 14, 2022

Making and using eco-friendly zinc oxide nanoparticles from gum Acacia modesta on surgical stitches to improve wound healing

Regenerative Health Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 10, 2026

Abstract

Zinc oxide nanoparticles (ZnO-NPs) were synthesized with an average size of 70 ± 3 nm and demonstrated significant antibacterial properties.

Suturing materials coated with ZnO-NPs showed good tensile strength suitable for surgical applications.
The nanoparticles exhibited effective antibacterial activity against Escherichia coli and Methicillin-resistant staphylococcus aureus (MRSA).
In an animal model, the designed sutures facilitated rapid epithelialization and wound contraction, with observed mild inflammation.
Histopathological analysis indicated enhanced collagen fibers and fibroblast cells, alongside lower inflammatory cells and rapid angiogenesis in healed tissues compared to standard treatments.
The improved wound healing responses are associated with the higher antibacterial activity of ZnO-NPs.

Simplified

In the present research, we developed zinc oxide nanoparticles (ZnO-NPs) based surgical sutures for the accelerated wound healing process. Color change from transparent to dark, surface plasmon response with a peak at 270 nm and infra-red spectra with ZnO-bond stretches at 489.6831 cmconfirmed the synthesis of NPs. Rod shape ZnO-NPs with an ideal size of 70 ± 03 nm were noted with uniform distribution. X-rays diffraction patterns revealed sharp peaks which was a clear indication of the crystalline nature of NPs. The energy dispersive X-ray analysis of synthesized nanoparticles reveals that the expected stoichiometric mass percent of zinc and oxygen is 77.55% and 22.45% respectively. Disc-diffusion antibacterial assay revealed that synthesized NPs hold good anti-bacterial potential against the Escherichia coli and Methicillin-resistant staphylococcus aureus (MRSA). Gum based ZnO-NPs coated suture revealed good tensile strength which is considered as a necessary parameter for suturing purposes. The designed suture showed excellent wound healing potential in Sprague-dawley rats through the incision wound model. Overall, in rats, rapid rate of epithelialization, wound contraction, mild inflammation and absence of any infection on the wounded site were recorded. Additionally, histopathology showed enhanced collagen fibers, fibroblast cells, lower inflammatory cells and rapid angiogenesis at healed tissues as compared to standard surgical treatment. Conclusively, the improved wound healing responses of the AM-ZnO-NPs were obtained due to the higher antibacterial activity of NPs. -1

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Making and using eco-friendly zinc oxide nanoparticles from gum Acacia modesta on surgical stitches to improve wound healing

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