How daily changes in DNA loops between gene switches and starters influence behavior

Disruption of enhancer-promoter contacts within chromatin leads to an advance in the 'wake-up' time of mice.

• Clock genes encode transcription factors that are expressed across various tissues.
• Time of day-dependent changes in chromatin are linked to core clock oscillations.
• The assembly of active chromatin domains involves the sequential recruitment of core clock transcription factors daily.
• Waking up is associated with significant changes in the three-dimensional arrangement of genes within cells.

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