A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila

Inhibition of highwire-encoded E3 ubiquitin ligase activity allows for single-trial long-term memory induction in aversive olfactory conditioning.

• Long-term memory (LTM) for aversive olfactory conditioning typically requires ten training trials.
• Single-trial LTM induction is achieved by inhibiting specific neuronal protein activity in the mushroom body.
• The targeted neurons are located in the α/β core region of the mushroom body.
• The synaptic output of these neurons plays a crucial role in memory consolidation shortly after training.
• These neurons appear to function as a 'gate' that regulates the formation of LTM based on the type of experience.

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