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Clock neurons in the side-top brain help form and keep long-term memory in fruit flies

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Disruption of synaptic transmission in dorsal-lateral clock neurons (LNds) impaired long-term memory (LTM) maintenance.

  • The circadian clock gene period (per) is crucial for the consolidation of long-term memory.
  • Specific clock neurons, particularly LNds, are essential for maintaining long-term memory.
  • Impairing LTM consolidation occurs when per RNA interference or a dominant-negative version of Per is induced in LNds.
  • Transmitter release and Per function in LNds are associated with the processing of courtship memory.

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