Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila

Nov 17, 2012Learning & memory (Cold Spring Harbor, N.Y.)

Fan-shaped body neurons help control long-term courtship memory over time in fruit flies

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Abstract

Overexpression of the Drosophila gene period (per) in specific brain neurons enhances long-term memory (LTM).

  • Knocking down per in subsets of brain neurons suppresses LTM.
  • Suppression of synaptic transmission during memory retrieval in these neurons leads to defective LTM.
  • The fan-shaped body region of the brain is critical for per-dependent regulation of LTM.
  • This brain region is also involved in improving courtship LTM during sleep.

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