Proceedings of the National Academy of Sciences of the United States of America

Importin-7 helps memory formation by controlling movement of active MAPK into the nucleus in fruit flies

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Silencing Drosophila importin-7 (DIM-7) results in impaired long-term memory (LTM) consolidation.

  • DIM-7 regulates the import of training-activated MAPK into the nucleus, which is crucial for LTM consolidation.
  • Overexpression of DIM-7 enhances LTM, suggesting a dose-dependent effect on memory processes.
  • The regulation of LTM by DIM-7 occurs within a specific time window during memory consolidation.
  • In mushroom body neurons, changes in DIM-7 expression lead to proportional alterations in the levels of activated MAPK in the nucleus.
  • The nuclear accumulation of activated MAPK, regulated by DIM-7, is linked to training specific for LTM induction.

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Competing interests

The authors declare no conflict of interest.
PubMed

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