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Aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: Bridging RORA gene polymorphism with diurnal mood variation in major depressive disorder
Unusual communication between the brain's internal clock and hearing areas links a RORA gene variant to daily mood changes in major depression
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Abstract
A total of 208 patients with major depressive disorder showed significant associations between the RORA gene polymorphism rs72752802 and diurnal mood variation symptoms.
- C allele carriers of the RORA rs72752802 polymorphism exhibited significantly decreased functional connectivity between the right suprachiasmatic nucleus and right superior temporal gyrus.
- This decreased connectivity was correlated with the severity of diurnal mood variation symptoms in patients.
- The influence of the rs72752802 SNP on diurnal mood variation symptoms may occur through intermediary effects of the identified connectivity.
- The findings suggest a potential genetic and neurological basis for understanding diurnal mood variation in depressed patients.
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