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Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1/GLP-1R/cAMP/PKA/CREB/INS pathway
Achyranthes bidentata polysaccharide improves type 2 diabetes by gut bacteria producing short-chain fatty acids that activate the GLP-1 hormone pathway
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Abstract
Achyranthes bidentata polysaccharide (ABP) demonstrated a hypoglycemic effect in mice with type 2 diabetes mellitus (T2DM).
- ABP repaired the intestinal barrier in T2DM mice.
- Treatment with ABP regulated the composition and abundance of gut microbiota, notably increasing bacteria that produce short-chain fatty acids (SCFAs).
- Increased levels of SCFAs were associated with higher glucagon-like peptide-1 (GLP-1) levels.
- The abundance of specific gut bacteria showed a positive correlation with blood lipid and insulin levels, while being negatively correlated with fasting blood glucose levels.
- The beneficial effects of ABP were linked to the activation of the GLP-1/GLP-1 receptor pathway and subsequent signaling cascades.
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