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Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract
Acrolein causes muscle cell death through a specific gene pathway that may be protected by asparagus extract
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Abstract
Acrolein exposure reduced the survival rate of vascular smooth muscle cells (VSMCs) and increased apoptosis.
- Acrolein exposure raised the percentage of apoptotic VSMCs by increasing pro-apoptotic factors and decreasing anti-apoptotic factors.
- The expression of long noncoding RNA NEAT1 and circadian clock genes Bmal1 and Clock was decreased by acrolein.
- Knockdown of NEAT1, Bmal1, or Clock led to increased VSMCs apoptosis through alterations in apoptosis-related proteins.
- Overexpression of NEAT1 inhibited VSMCs apoptosis, suggesting a protective role.
- Asparagus extract (AE) mitigated the apoptotic effects and circadian disruptions induced by acrolein.
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