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Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract
How NEAT1 controls body clock rhythms through TMAO-driven blood vessel growth and the protective effect of asparagus extract
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Abstract
TMAO exposure for 24 hours inhibited cell proliferation of human umbilical vein endothelial cells (HUVECs).
- TMAO increased the expression of lncRNA-NEAT1, Clock, and Bmal1 while inhibiting MAPK pathways.
- Elevated levels of Clock and Bmal1 were observed when MAPK pathways were blocked.
- NEAT1 exhibited a circadian rhythm in HUVECs, and its overexpression led to reduced cell proliferation.
- Manipulating NEAT1 levels influenced the expression of Clock and Bmal1, as well as the activity of MAPK pathways.
- Asparagus extract improved the proliferation of HUVECs that was reduced by TMAO and corrected the disturbances in NEAT1, Clock, Bmal1, and MAPK signaling pathways.
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