How eating a high-fat meal at different times of day quickly affects metabolism flexibility in mice

Mice consuming a very high fat diet early in their waking cycle had a 13.2% higher caloric intake from fat compared to those fed at a later time.

• Feeding time and fat content of the diet may affect substrate metabolism in mice.
• Mice in the early very high fat or high fat groups had lower daily average respiratory exchange ratios.
• No significant changes in glucose tolerance, body fat composition, or weight were observed after 9 days of restricted feeding.
• Disruption of the adipocyte circadian clock did not alter the metabolic response to different feeding times.

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