Time-Restricted Feeding and Caloric Restriction: Two Feeding Regimens at the Crossroad of Metabolic and Circadian Regulation

May 24, 2022Methods in molecular biology (Clifton, N.J.)

Time-Restricted Feeding and Calorie Cutting: How Two Diet Plans Affect Metabolism and Body Clock

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Abstract

Time-restricted feeding (TRF) and caloric restriction (CR) are proposed as key methods to study nutritional and metabolic health.

Nutrition timing, alongside diet quality and quantity, may significantly influence metabolic health.
Daily feeding and fasting cycles are regulated by the body's circadian clock, impacting metabolic processes.
Preclinical studies in rodents could help clarify the relationship between feeding regimens and metabolic homeostasis.
Methods for analyzing the effects of TRF and CR include examining changes in the circadian clock's activity and conducting glucose tolerance tests.

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In addition to diet quality and quantity, the "timing" of food intake recently emerged as a third key parameter in nutritional and metabolic health. The link between nutrition timing and metabolic homeostasis is in part due to the regulation of daily feeding:fasting cycles and metabolic pathways by the circadian clock. Preclinical feeding regimen studies in rodents are invaluable to further define the modalities of this relationship and get a better understanding of its mechanistic underpinnings. Time-restricted feeding (TRF) and caloric restriction (CR) are examples of feeding regimen at the crossroads of metabolic and circadian regulation. Here we propose methods to implement TRF and CR highlighting the parameters that are relevant to the study of circadian and metabolic health. We also provide methods to determine their impact on the output of the circadian clock by analyzing diurnal expression profiles using 24 h time-series collection as well as their impact on metabolic homeostasis using a glucose tolerance test (GTT).

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Time-Restricted Feeding and Caloric Restriction: Two Feeding Regimens at the Crossroad of Metabolic and Circadian Regulation

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