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Nutrition and the circadian system
How Nutrition Affects the Body’s Internal Clock
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Abstract
High-fat diets disrupt feeding/fasting cycles and may negatively affect circadian system organisation.
- The human circadian system adapts to environmental changes to optimize behavior based on the time of day.
- The master clock, located in the suprachiasmatic nuclei of the anterior hypothalamus, is primarily synchronized by light/dark cycles.
- Feeding/fasting cycles serve as critical time cues for peripheral tissues' clocks.
- Misalignment of feeding times with clock-regulated metabolic changes could lead to adverse metabolic outcomes and chronic diseases.
- Time-of-day-restricted feeding may mitigate some negative impacts of high-fat diets observed in rodents.
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