Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

Jul 4, 2014European journal of applied physiology

Short-term low-oxygen exercise does not change iron levels after exercise in moderately trained endurance athletes

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Abstract

Hepcidin levels significantly increased 3 hours post-exercise in both hypoxic and normoxic conditions.

Peak heart rate was significantly lower during hypoxic exercise compared to normoxic exercise.
Ferritin, transferrin, and Interleukin-6 levels significantly increased immediately post-exercise in both conditions.
Ferritin, transferrin, and IL-6 levels returned to baseline 3 hours post-exercise.
No significant differences in hepcidin levels were observed between hypoxic and normoxic conditions immediately after exercise.
A significant treatment effect was found for soluble transferrin receptor levels between trials, while no significant differences were noted for iron and transferrin saturation.

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PURPOSE: This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes.

METHODS: In a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (F IO2) = 0.2093, 15.3 ± 1.7 km h(-1)] and simulated hypoxic (HYP, F IO2 = 0.1450, 13.2 ± 1.5 km h(-1)) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation.

RESULTS: Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation.

CONCLUSION: Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.

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Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

Abstract

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