Influence of post-exercise hypoxic exposure on hepcidin response in athletes

Feb 4, 2014European journal of applied physiology

How low oxygen after exercise affects hepcidin levels in athletes

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Abstract

Simulated altitude exposure (~2,900 m) significantly lowers peak hepcidin levels at 3 hours post-exercise compared to normoxic conditions.

Interleukin-6 levels increased significantly immediately post-exercise in both recovery conditions but did not differ between them.
Hepcidin levels were significantly higher at 3 hours post-exercise for both recovery conditions compared to baseline, but lower in the hypoxic condition.
No significant differences were found between hypoxic and normoxic conditions for erythropoietin, serum iron, or ferritin levels.
A hypoxic recovery period may support athletes with low iron status by enhancing acute dietary iron absorption.

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PURPOSE: To assess the influence of a simulated altitude exposure (~2,900 m above sea level) for a 3 h recovery period following intense interval running on post-exercise inflammation, serum iron, ferritin, erythropoietin, and hepcidin response.

METHODS: In a cross-over design, ten well-trained male endurance athletes completed two 8 × 3 min interval running sessions at 85 % of their maximal aerobic velocity on a motorized treadmill, before being randomly assigned to either a hypoxic (HYP: F IO2 ~0.1513) or a normoxic (NORM: F IO2 0.2093) 3 h recovery period. Venous blood was collected pre- and immediately post-exercise, and after 3 and 24 h of recovery. Blood was analyzed for interleukin-6, serum iron, ferritin, erythropoietin, and hepcidin.

RESULTS: Interleukin-6 was significantly elevated (p < 0.01) immediately post-exercise compared to baseline (NORM: 1.08 ± 0.061 to 3.12 ± 1.80) (HYP: 1.32 ± 0.86 to 2.99 ± 2.02), but was not different between conditions. Hepcidin levels were significantly elevated (p < 0.01) at 3 h post-exercise for both conditions when compared to baseline (NORM: 3.25 ± 1.23 to 7.40 ± 4.00) (HYP: 3.24 ± 1.94 to 5.42 ± 3.20), but were significantly lower (p < 0.05) in the HYP trial compared to NORM. No significant differences existed between HYP and NORM for erythropoietin, serum iron, or ferritin.

CONCLUSION: Simulated altitude exposure (~2,900 m) for 3 h following intense interval running attenuates the peak hepcidin levels recorded at 3 h post-exercise. Consequently, a hypoxic recovery after exercise may be useful for athletes with compromised iron status to potentially increase acute dietary iron absorption.

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Influence of post-exercise hypoxic exposure on hepcidin response in athletes

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