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Aging happens over time but not through a fixed plan
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Abstract
Aging clocks may reflect the accumulation of molecular errors rather than an intrinsic biological program.
- Debate exists over the causes of aging, with recent aging clocks suggesting a biological program.
- The decline of natural selection post-reproduction may lead to cellular deterioration without a specific program.
- Aging is associated with the stochastic accumulation of damage due to inadequate maintenance and repair.
- Cross-species comparisons show that better DNA repair capacity correlates with greater longevity in mammals.
- Understanding the randomness in aging could provide insights for developing interventions to promote healthy aging.
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