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ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m6A-YTHDF2 dependent manner to activate HK-2 signaling
ALKBH5 may promote infantile hemangioma growth by increasing FOXF1 through m6A-YTHDF2 to activate energy metabolism signaling
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Abstract
FOXF1 expression was overexpressed in infantile hemangioma tissues.
- Silencing FOXF1 inhibited proliferation, migration, and invasion of infantile hemangioma cells while promoting apoptosis.
- ALKBH5 upregulation was associated with increased stability and expression of FOXF1 mRNA in infantile hemangioma cells.
- FOXF1 downregulation reversed the effects of ALKBH5 on cellular behaviors in infantile hemangioma.
- FOXF1 positively influenced hexokinase 2 (HK-2) expression by interacting with its promoter in infantile hemangioma cells.
- Suppression of ALKBH5 or FOXF1 reduced tumor growth in infantile hemangioma in immunocompromised mice through HK-2 signaling.
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