Apolipoprotein A-IV Expression in Mouse Liver Enhances Triglyceride Secretion and Reduces Hepatic Lipid Content by Promoting Very Low Density Lipoprotein Particle Expansion

Hepatic steatosis can induce hepatic apoA-IV expression by up to 43-fold.

• Increased hepatic apoA-IV mRNA and protein levels correlate positively with hepatic triglyceride content (r(2)=0.8965).
• ApoA-IV induction led to a 24% reduction in hepatic triglyceride secretion rate in SREBP-1a(Tg)/Apoa4 knockout mice compared to controls.
• Electron microscopy showed a 33% decrease in secreted very low density lipoprotein particles with diameters ≥ 120 nm in the knockout mice.
• Infection with a recombinant human apoA-IV adenovirus resulted in a 52% increase in hepatic triglyceride secretion rate and a 38% reduction in liver triglyceride content.
• Large diameter (≥ 120 nm) very low density lipoprotein particles increased by 43% in mice with recombinant apoA-IV, without a change in apoB secretion.

AI simplified